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Robotic Lab Assistant

PUBLICATIONS

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2024

  1. Wang Y, MA B, Jian Y, Wu S-T, Wong A, Wong JJL, Bonder EM, Zheng X. (2024) Deficiency of Pdcd10 causes urothelium hypertrophy and vesicle trafficking defects in ureter. FEBS J. 291:1008-1026

2023

  1. Lee Q, Song R, Phan DAV, Pinello N, Tieng J, Su A, Halstead JM, Wong ACH, van Geldermalsen M, Lee BSL, Rong B, Cook KM, Larance M, Liu R, Lan F, Tiffen JC, Wong JJL. (2023) Overexpression of VIRMA confers vulnerability to breast cancers via the m6A-dependent regulation of unfolded protein response. Cell Mol Life Sci. 80:157

  2. Huang H, Song R, Wong JJL, Anggono V, Widagdo J. (2023) The N6-methyladenosine landscape in the aged mouse hippocampus. Aging Cell. 22:e13755 

  3. Song R, Wong JJL. (2023) Altered expression of m1 A regulatory genes is associated with oncogenic pathways, overall survival, and infiltration of immune cells in diverse human cancers. Genes Dis. 10: 739-742

  4. Hitchins MP, Alvarez R, Zhou L, Aguirre F, Dámaso E, Pineda M, Capella G, Wong JJL, Yuan X, Ryan SR, Sathe DS, Baxter MD, Cannon T, Biswas R, DeMarco T, Grzelak D, Hampel H, Pearlman R. (2023) MLH1-methylated endometrial cancer under 60 years of age as the “sentinel” cancer in female carriers of high-risk constitutional MLH1 epimutation. Gynecol Oncol. 171:129-140

  5. Zhang J, Yang J, Duval C, Edin ML, Williams A, Lei L, Tu M, Pourmand E, Song R, Graves JP, DeGraff LM, Wong JJL, Wang Y, Sun Q, Sanidad KZ, Wong S, Han Y, Zhang Z, Lee KSS, Park Y, Xiao H, Liu Z, Decker EA, Cui W, Zeldin DC, Zhang G. (2023) CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J. 7:e23009

2022

  1. Song R, Tikoo S, Jain R, Pinello N, Au AYM, Nagarajah R, Porse B, Rasko JEJ, Wong JJL. (2022) Dynamic intron retention modulates gene expression in the monocytic differentiation pathway. Immunology. 265:274-286.

  2. Chen X, Zhou W, Song R, Liu S, Wang S, Chen Y, Gao C, He C, Xiao J, Zhang L, Wang T, Liu P, Duan K, Cheng Z, Zhang C, Zhang J, Sun Y, Jackson F, Lan F, Liu Y, Xu Y, Wong JJL, Wang P, Yang H, Xiong Y, Chen T, Li Y, Ye D. (2022) Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Sci Adv. 8:eabl5220.

  3. Widagdo J, Wong JJL, Anggono V. (2022) The m6a epitranscriptome in brain plasticity, learning and memory. Sem Cell Dev Biol. 125:110-121.

  4. Widagdo J, Anggono V, Wong JJL. (2022) The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends Genet. 38:325-332.

  5. Hortle E, Tran LV, Fontaine ARM, Pinello N, Wong JJL, Britton WJ, Oehlers SH. (2022) OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Sci Alliance. 5(9).

  6. Wong JJL, Schmitz U. Intron retention: importance, challenges and opportunities. Trends Genet. 38:789-792.

  7. Zhu S, Rao X, Qian Y, Chen J, Song R, Yan H, Xi Y,, Hu J, Wang X, Han Z, Zhu Y, Liu R, Wong JJL, Mc-Caughan GW, Zheng X. (2022) Liver endothelial Heg regulates vascular/biliary network patterning and metabolic zonation via Wnt signaling. Cell Mol Gastroenterol Hepatol. 13:1757-1783.

  8. Petrova V, Song R, Nordström KJV, Walter J, Wong JJL, Armstrong NJ, Rasko JEJ, Schmitz U. (2022) Increased chromatin accessibility facilitates intron retention in specific cell differentiation states. Nucleic Acids Res. 50:11563-11579

  9. Shah JS, Milevskiy MJG, Petrova V, Au AYM, Wong JJL, Visvader JE, Schmitz U, Rasko JEJ. (2022) Towards resolution of the intron retention paradox in breast cancer. Breast Cancer Res. 24:10

2021

  1. Alharbi AB, Schmitz U, Marshall AD, Vanichkina D, Nagarajah R, Vellozzi M, Wong JJL, Bailey CG, Rasko JEJ. (2021) Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner. RNA Biol 18:93-103.

  2. Choi JP, Yang X, He S, Song R, Xu Z-R, Foley M, Wong JJL, Xu C-R, Zheng X. (2021) CCM2L (Cerebral Cavernous Malformation 2 Like) deletion aggravates cerebral cavernous malformation through Map3k3-KLF signalling pathway. Stroke 52:1428-1436.

  3. Wang R, Wu S-T, Yang X, Qian Y, Choi JP, Gao R, Song S, Wang Y, Zhuang T, Wong JJL, Zhang Y, Han Z, Lu HA, Alexander SI, Liu R, Xia Y, Zheng X. (2021) Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting. JCI Insights 6:e142838.

  4. Green ID, Liu R, Wong JJL. (2021) The expanding role of alternative splicing in vascular smooth muscle cell plasticity. Int J Mol Sci 22:10213.

2020

  1. Lee Q, Padula MP, Pinello N, Williams SH, O’Rourke MB, Fumagalli MJ, Orkin JD, Song R, Shaban B, Brenner O, Pimanda JE, Weninger W, de Souza WM, Melin AD, Wong JJL, Crim MJ, Monette S, Roediger B, Jolly CJ (2020) Murine and related chappaparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. PloS Pathogens 16:e1008262.

  2. Li X, Li N, Huang L, Xu S, Hamsathd A, Dai L, Zhang M, Zhang H, Zheng X, Wong JJL, Xian M, Yang C, Liu J. (2020) Is hydrogen sulfide a concern during treatment of lung adenocarcinoma with ammonium tetrathiomolybdate? Front Oncol 10:234.

  3. Green ID, Pinello N, Song R, Lee Q, Halstead JM, Kwok C-T, Wong ACH, Nair SS, Clark SJ, Roediger B, Schmitz U, Larance M, Hayashi R, Rasko JEJ, Wong JJL. (2020) Macrophage development and activation involve coordinated intron retention in key inflammatory regulators. Nucleic Acids Res 48:6513-6529.

  4. Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B & Fuks F. (2020) Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Commun 11: 4956.

  5. Schmitz U, Shah JS, Dhungel BP, Monteuuis G, Luu P-L, Petrova V, Metierre C, Nair SS, Bailey CG, Saunders VA, Turhan AG, White DL, Branford S, Clark SJ, Hughes TP, Wong JJL, Rasko JEJ. (2020) Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients. Cancers 12:3738

2019

  1. Gao D, Pinello N, Nguyen TV, Thoeng A, Nagarajah R, Holst J, Rasko JEJ, Wong JJL#. (2019) DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis. Epigenomics 11:95-109. #Corresponding author

  2. Monteuuis G, Wong JJL, Bailey CG, Schmitz U, Rasko JEJ. (2019) The changing paradigm of intron retention: regulation, ramifications and recipes. Nucleic Acids Res. gkz1068

2018

  1. Wong ACH, Rasko JEJ, Wong JJL. (2018) We skip to work: Alternative splicing in normal and malignant myelopoiesis. Leukemia 32:1081-1093.

  2. Rajasekhar M, Schmitz U, Flamant S, Wong JJL, Bailey CG, Ritchie W, Holst J, Rasko JEJ. (2018) Identifying microRNA determinants of human myelopoiesis. Scientific Rep. 8:7264.

  3. Nair SS, Luu P-L, Qiu, W, Maddugoda M, Huschtscha L, Reddel, R, Chenevix-Trench G, Toso M, Kench JG, Horvath LG, Hayes VM, Stricker PD, Hughes TP, White DL, Rasko JEJ, Wong JJL, Clark SJ. (2018) Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumna HiSeq X Ten. Epigenetics Chromatin 11:24.

  4. Cook SJ, Lee Q, Wong ACH, Spann BC, Vincent JN, Wong JJL, Schlitzer A, Gorell MD, Weninger W, Roediger B. (2018) Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunol Cell Biol. 96:1131-1139.

  5. Roediger B, Lee Q, Tikoo S, Cobbin JCA, Henderson JM, Jormakka M, O'Rourke  MB, Padula MP, Pinello N, Henry M, Wynne M, Santagostino SF, Brayton CF, Rasmussen L, Tay SS, Harris DC, Bertram JF, Dowling JP,  Bertolino P, Lai JH, Wu W, Bachovchin WW, Wong JJL, Gorrell M, Shaban B, Holmes EC, Jolly CJ, Monette S and Weninger W. (2018) An atypical provirus driving chronic tubulointerstitial nephropathy and kidney fibrosis. Cell 175:530-543.e24.

  6. Pinello N, Sun S, Wong JJL. (2018) Aberrant expression of enzymes regulating m6A mRNA methylation: implication in cancer. Cancer Biol and Med. 15:323-334.

2017

  1. Rasko JEJ, Wong JJL#. (2017). Nuclear miRNAs in normal hemopoiesis and cancer. J Hematol Oncol. 10:8 #Corresponding author 

  2. Kwok C-T, Marshall AD, Rasko JEJ, Wong JJL#. (2017) Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia. J Hematol Oncol. 10:39 #Corresponding author

  3. Wong JJL*#, Gao D*, Nguyen TV*, Kwok C-T, van Geldermalsen M, Middleton R, Pinello N, Thoeng A, Nagarajah R, Holst J, Ritchie W#, Rasko JEJ#. (2017) Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment. Nat Commun. 8:15134  *Equal first #Corresponding authors

  4. Middleton R, Gao D, Thomas A, Singh B, Au A, Wong JJL, Bomane A, Cosson B, Eyras E, Rasko JEJ, Ritchie W. (2017) IRFinder: Assessing the impact of intron retention on mammalian gene expression. Genome Biol. 18:51.

  5. Tan MC, Wigdado J, Chau YQ, Zhu T, Wong JJL, Cheung A, Anggono V. (2017) The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Front Cell NeuroSci. 11:124.

  6. Vanichkina D, Schmitz U, Wong JJL, Rasko JEJ. (2018) Intron retention presents unique challenges to define its role in normal biology and disease. Sem Cell Dev Biol. 75:40-49.

  7. Schmitz U, Pinello N, Jia F, Alasmari S, Ritchie W, Keightley MC, Shini S, Lieschke G, Wong JJL†, Rasko JEJ†. (2017) Intron retention enhances gene regulatory complexity in vertebrates. Genome Biol. 18:216. † Equal last

2016

  1. Wong JJL*, Au AYM*, Ritchie W, Rasko JEJ. (2016) Intron retention: no longer nonsense. BioEssays. 38:41-49. *Equal first.

  2. Wong JJL, Au AYM, Gao D, Pinello N, Kwok C-T, Thoeng A, Lau KA, Gordon JEA, Schmitz U, Feng Y, Nguyen TV, Middleton R, Bailey CG, Holst J, Rasko JEJ, Ritchie W. (2016) RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Res. 44:2888-2897.

  3. Edwards CR, Ritchie W, Wong JJL, Schmitz U, Middleton R, An X, Narla M, Rasko JEJ, Blobel GA. (2016) A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood. 127:e24-e34.

2015

  1. Wang Q, Hardie R-A, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ, Metierre C, Pinello N, Otte NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JE, Holst J. (2015) Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol. 236:278-289.

2014

  1. Wong JJL, Ritchie W, Gao D, Lau KA, Gonzalez M, Choudhary A, Taft RJ, Rasko JEJ, Holst J. (2014) Identification of nuclear-enriched miRNAs during mouse granulopoiesis. J Hematol Oncol. 7:42. 

  2. Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee D-S, Shin J-Y, Wong JJL, Bailey CG, Benevento M, Chuah A, Wood D, Rasko JEJ, Heck AJR, Grimmond SM, Rogers IM, Seo J-S, Wells CA, Puri MC, Nagy A, Preiss T. (2014) Small RNA changes en route to distinct cellular states of induced pluripotency. Nat Commun. 5:5522. 

  3. Wong JJ-L#, Holst J. (2014) Changes in CpG methylation marks differentiation of human myeloid progenitors to neutrophils. Stem Cell Invest. 1:10. #Corresponding author

  4. Wong, JJ-L, Lau, KA, Pinello, N, Rasko, JEJ. (2014) Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer Sci. 105:1457-1463.

2013

  1. Gordon, J.E.A.*, Wong, J.J.*, Rasko, J.E.J. (2013) miRNAs in myeloid malignancies. Brit J Haematol. 162:162-176. *Equal first

  2. Lau KA and Wong JJ. (2013) Current Trends in HIV Recombination. Infectious Disease Reports. 5: 1S. 

  3. Wong JJL*, Ritchie W*, Ebner O, Selbach M, Wong JWH, Huang Y, Gao D, Pinello N, Gonzalez M, Baidya K, Thoeng A, Khoo T-L, Bailey CG, Holst J & Rasko JEJ. (2013) Orchestrated intron retention regulates normal granulocyte differentiation. Cell 154:583-595.  *Equal first

2011​

  1. Wong JJL, Hawkins NJ, Ward RL and Hitchins MP. (2011) Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer. Mod Pathol. 24: 396-411.

  2. Hitchins, MP, Rapkins, RW, Kwok, C-T, Srivastava, S, Wong, JJ, Khachigian, LM, Polly, P, Goldblatt, J, Ward, RL. (2011) Dominantly inherited constitutional epigenetic ailencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5’UTR. Cancer Cell 20: 200-213. (IF: 22.844; Cit: 110)

2010

  1. Taft, RJ, Simons C, Nahkuri S, Oey H, Korbie DJ, Mercer TR, Holst J, Ritchie W, Wong JJL, Rasko JEJ, Rokhsar DS, Degnan BM, Mattick JS. (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nat Struct Mol Biol. 17, 1030-1034.

2009

  1. Hawkins, NJ, Lee JH, Wong JJ, Kwok C-T, Ward RL, Hitchins MP. (2009). MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. Mod Pathol. 22, 1588-1599.

2007

  1. Wong JJL, Hawkins NJ and Ward RL (2007). Colorectal cancer - a model for epigenetic tumourigenesis. Gut. 56: 140-148. 

  2. Hitchins M, Suter, C, Wong, J, Cheong, K, Hawkins, N, Leggett, B, Scott, R, Spigelman, A, Tomlinson, I, Martin, D and Ward, R (2006). Germline epimutations of APC are not associated with inherited colorectal polyposis. Gut. 55: 586-587.

Publications: Citations
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